4-[(E)-4-Hydroxybut-2-en-1-yl]-2-methoxyphenol

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(S)-2-[(S,E)-4-(4-Chloro­phen­yl)-1-nitro­but-3-en-2-yl]cyclo­hexa­none

The title compound, C(16)H(18)ClNO(3), was obtained by the organocatalytic asymmetric Michael addition of cyclo-hexa-none to 1-chloro-4-[(1E,3E)-4-nitro-buta-1,3-dien-yl]benzene. The double bond has an E configuration. The cyclo-hexa-none ring adopts a chair conformation. The conformation of the mol-ecule is stabilized by a weak intra-molecular C-H⋯O hydrogen bond.

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In the title compound, C(22)H(24)N(4)O, the terminal and central benzene rings make dihedral angles of 52.7 (3) and 43.8 (2)°, respectively, with the triazole ring. The dihedral angle between the benzene rings is 8.9 (2)°. The crystal structure features C-H⋯π inter-actions. The atoms of the terminal propenyl group are disordered over two sets of sites, with a refined occupancy ratio of 0.714 (1...

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A series of (5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl derivatives 6a–6e have been synthesized and screened for in vitro anti-leishmanial activity against the promastigote form of L. major. The structure of Schiff bases were confirmed by 1H NMR, IR. Screening results indicate that all of the designed and synthesized final compounds (6a-6e) significantly reduced the viability of promastigotes ...

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The piperidine ring in the title compound, C(21)H(23)NO(2), is in a slightly distorted chair conformation. The dihedral angle between the two benzene rings is 5.6 (4)°. The dihedral angles between the propenone unit and the benzene and meth-oxy-substituted benzene rings are 5.6 (7) and 10.7 (8)°, respectively. Weak inter-molecular C-H⋯O hydrogen bonds and weak C-H⋯π inter-actions contribute to ...

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Synthesis and Leishmanicidal Activity of 1-[5-(5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl]-4-benzoylepiperazines

A series of (5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl derivatives 6a–6e have been synthesized and screened for in vitro anti-leishmanial activity against the promastigote form of L. major. The structure of Schiff bases were confirmed by 1H NMR, IR. Screening results indicate that all of the designed and synthesized final compounds (6a-6e) significantly reduced the viability of promastigotes ...

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ژورنال

عنوان ژورنال: IUCrData

سال: 2016

ISSN: 2414-3146

DOI: 10.1107/s2414314616009366